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| Supplementary Figure 1: Confocal image of the glabrous skin biopsy taken from 8 months old control rats. The image shows that the dermal nerves are situated along the basement membrane and send fine branches through the membrane and into the epidermis. |
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| Supplementary Figure 2: Confocal image of the glabrous skin biopsy taken from 8 months old control rats. The image shows that the dermal nerves are situated along the basement membrane and send fine branches through the membrane and into the epidermis. |
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| Supplementary Figure 3: Confocal image of the glabrous skin biopsy taken from 18 months old control rats. The image shows that the dermal nerves are situated along the basement membrane and send fine branches through the membrane and into the epidermis. |
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| Supplementary Figure S4: Confocal image of the glabrous skin biopsy taken from 18 months old control rats. The image shows that the dermal nerves are situated along the basement membrane and send fine branches through the membrane and into the epidermis. |
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| Supplementary Figure 5: Confocal image of the glabrous skin biopsy taken from 8 months old control rats. The image shows that the dermal nerves are situated along the basement membrane and send fine branches at right angle through the membrane and into the epidermis. |
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| Supplementary Figure 6: Confocal image of the glabrous skin biopsy taken from 2 months old control rats. The image shows epidermal nerves arise from the sub-epidermal neural plexus and penetrate the basement membrane. Upon entry into the epidermis, axons follow a tortuous course. |
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| Supplementary Figure 7: Confocal image of the glabrous skin biopsy taken from 2 months old control rats. The image shows epidermal nerves arise from the sub-epidermal neural plexus and penetrate the basement membrane. Upon entry into the epidermis, axons follow a tortuous course |
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| Supplementary Figure 8: Confocal image of the glabrous skin biopsy taken from 18 months old control rats. The image shows epidermal nerves arise from the sub-epidermal neural plexus and penetrate the basement membrane. Upon entry into the epidermis, axons follow a tortuous course. |
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| Supplementary Figure 9: Confocal image of the glabrous skin biopsy taken from 24 months old control rats. The image shows epidermal nerves fibers extend up to the superficial layers of the epidermis without branching. |
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| Supplementary Figure 10: Confocal image of the glabrous skin biopsy taken from 18 months old control rats. The image shows epidermal nerves fibers cross adjacent fibers to form a ‘kissing fiber’ configuration. |
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| Supplementary Figure 11: Confocal image of the glabrous skin biopsy taken from 8 months old control rats. The image shows epidermal nerves fibers cross adjacent fibers to form a ‘kissing fiber’ configuration. |
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| Supplementary Figure 12: Confocal image of the glabrous skin biopsy taken from 24 months old control rats. The image shows most pronounced reduction in epidermal innervation was observed in samples from the >24 mo rats, as they lacked intact fibers within the epidermis, although dermal fibers were present |
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| Supplementary Figure 13: Confocal image of the glabrous skin biopsy taken from 24 months old control rats. The image shows most pronounced reduction in epidermal innervation was observed in samples from the >24 mo rats, as they lacked intact fibers within the epidermis, although dermal fibers were present. |
